Samento®: New Remedy For An
Ancient Enemy—Lyme Disease
by James South, M.A
Vitamin Research News, Vol. 18, Number 6, July 2004
Lyme disease was first recognized around 1975, when a mysterious outbreak of
juvenile rheumatoid arthritis occurred around Lyme, Connecticut.1 In 1982, the
causative agent of Lyme disease was discovered by Willy Burgdorfer. It turned out to
be a spirochete (spiral-shaped bacterium) from the genus Borrelia, subsequently
named Borrelia burgdorferi (Bb).1
As Lyme disease expert Jo Anne Whitaker, M.D., notes: “Lyme disease is called the
‘New Great Imitator’ because, like syphilis [the original ‘Great Imitator’], it attacks
multiple organ systems and mimics many diseases. Both diseases are caused by
spirochetes.”2 Originally believed to be spread only through bites by the tiny deer
tick (Ixodes dammini), it is now known to be potentially spread by many tick species,
as well as bot-flies, mosquitoes and fleas.3,4
And in a recent article with 224 references, physicians W.T. Harvey and P. Salvato
have offered persuasive evidence that Lyme disease is transmitted sexually and
congenitally (by birth from an infected mother), as well as through breastfeeding.1,4
They also provide evidence that Lyme disease may be a hidden epidemic, affecting
as much as one-sixth of the human race, if not more.4 By 1994, Lyme disease
experts Brian Fallon and Jenifer Nields could already state: “Now the most common
vector-borne [spread by ticks and insects] infection in the United States, Lyme
disease is increasing in incidence and geographic spread.”5
Lyme: One Disease, Many Symptoms
Lyme disease is believed to cause, mimic, manifest as, be misdiagnosed as, or
contribute to more than 300 conditions and diseases.6 About 60 percent of those
bitten by Bb-infected ticks or insects will develop a characteristic “bulls-eye” rash
(erythema migrans), yet many confirmed Lyme disease patients never develop such
There may be few initial symptoms other than a flu-like syndrome, yet within weeks
to years a diversity of symptoms may occur. These may include fatigue, low grade
fevers, night sweats, migrating joint pains or arthritis, muscle pains, sleep
disturbances, frequent and/or severe headaches, numbness or tingling in hands or
feet, nerve pains, brain fog, hypersensitivity to lights, sounds, tastes or smells,
memory and concentration problems, speech difficulties, depression, irritability,
mood swings,7 heart, eye, respiratory and gastrointestinal problems,2 to name just a
few. Symptoms may come and go, varying in intensity. The Bb spirochete may
penetrate into the brain as early as three weeks after infection.8
Lyme: Difficult and Controversial Diagnosis
Lyme disease has become a surprisingly controversial disease.9 Even famed
novelist Amy Tan has been drawn into the controversy, after a belated Lyme disease
diagnosis in her own case. She complained about being tested even for syphilis and
ALS (Lou Gehrig’s disease) before anyone thought to test her for Lyme disease.10
Why the controversy? The CDC (United States Centers for Disease Control and
Prevention) has set up a rather strict formal set of criteria for Lyme disease
diagnosis. The CDC is not directly involved in disease treatment. Its criteria are
designed as part of its mission to track and assess disease patterns in the United
Many conservative physicians use the CDC’s Lyme disease surveillance criteria as
clinical diagnostic criteria. A key part of the CDC criteria is a requirement for
laboratory confirmation through ELISA (enzyme-linked immunosorbent assay)
and/or Western blot antibody testing.8
Yet as Lyme disease expert Brian Fallon has written in America’s most prestigious
psychiatric textbook: “Although laboratory testing is a valuable component of the
diagnostic assessment, negative test results cannot be used to exclude Lyme
disease in a patient with typical clinical features and a history of exposure to a Lyme
disease endemic area…. Because the laboratory tests for chronic Lyme disease are
not sufficiently reliable to document the presence or absence of persistent infection,
decisions regarding treatment should be based primarily upon the physician’s clinical
For those wishing an accurate laboratory confirmation of Lyme disease, Dr. Jo Anne
Whitaker, M.D., has developed a new “Quantitative-Rapid Identification of Borrelia
burgdorferi” test (QRIBb©). Using a fluorescent antibody technique, Whitaker has
confirmed Lyme disease in 3,500 blood specimens from ill patients.Her results in
many cases were checked by world-renowned microbiologist Dr. LidaMattman, who
was able in every case to culture and identify live Bb spirochetes fromthe blood
samples the QRIBb test had already certified as Bb-positive. Dr. Whitakercan be
reached at 727-937-9077.
She has found many patients were given a false diagnosis (e.g., ALS) who turned
out to have Lyme disease, and in many cases recovered from “incurable” ailments
after antibiotic treatment.11
Lyme: Treatment Controversies
When Lyme disease is diagnosed, it is normally treated with antibiotics. Fallon states
that for early Lyme disease without central nervous system (CNS) involvement,
three to four weeks of oral doxycyline, amoxicillin or cefuroxime is recommended.8
For Lyme disease with CNS involvement, a four-to-six-week intravenous treatment
with ceftriaxione or cefotaxime is recommended.8 Fallon recommends that for
relapsing patients, longer and repeated courses of antibiotic treatment may be
useful.8 He notes, “Failure to treat Lyme disease early in its course or for a
sufficiently long duration may lead to a chronic illness characterized by persistent
waxing and waning neuropsychiatric disturbances, arthralgias [joint pains], myalgias
[muscle pains], sensory-hyperacuities, and severe fatigue.”8
Yet many conservative physicians treating Lyme disease give only a two-to-threeweek
course of antibiotics, frequently only orally. Because intravenous antibiotic
care may cost tens of thousand of dollars, medical insurers and medical benefit
managers often discourage or deny such treatment.
Not everyone approves of massive antibiotic treatment for Lyme disease. Dr David
Jernigan, co-author with his wife of a recent book on Lyme disease, observes that “It
is not enough simply to take an antibiotic: even intravenous antibiotics will only kill
85 percent of the bacteria at best, leaving 15 percent alive and now antibiotic
resistant…. Most people with chronic Lyme disease have already used many
antibiotics with limited success or may be intolerant and allergic to them.”12
Fallon and Nields point out “B. burgdorferi has been shown to be capable of
persisting in human hosts despite extensive antibiotic treatment…. Several features
are known to contribute to an organism’s resistance to standard lengths of antibiotic
treatment. These features include an intracellular location, long replication time,
genetic variability, and the ability to become sequestered in difficult-to-penetrate
sites. B. burgdorferi appears to possess all of these characteristics.”5 Bb has been
shown able to live inside various cells, including fibroblasts, macrophages, and
endothelial cells, as well as in antibiotic- and immunologically-privileged sites, such
as CNS, joints and the interior chamber of the eye, which protect it from immune
cells and antibiotics.5
Given the recognized difficulty of successfully treating Lyme disease with standard
antibiotic therapy, an alternative treatment that is natural, nontoxic, well-tolerated,
effective, and can be taken orally for as many months or years as needed, would be
a welcome remedy in the Lyme war.
Fortunately, such a remedy has been available since 2001. It is an herbal extract
called “Samento,” made from a Peruvian vine called “Uncaria tomentosa,” also
known as “cat’s claw,” “una de gato,” and “Vilcacora.”14 Samento is made from a
rare chemotype of U. tomentosa that is rich in pentacyclic oxindole alkaloids (POA)
and is guaranteed free of tetracyclic oxindole alkaloids (TOA). It is the TOA-free
nature of Samento, combined with its POA potency, that gives Samento its unique
Most cat’s claw products on the market contain a mixture of POA and TOA, in
unknown proportions. Yet K.-H. Reinhard has noted “…the root of Uncaria
tomentosa is a valuable drug only when its pentacyclic chemotype is used without
admixture of the tetracyclic chemotype. The pentacyclic oxindole alkaloids act on the
cellular immune system. They raise the rate of phagocytosis [germ-killing] by
granolucytes [a type of white blood cell]… and they induce the release of a factor
from endothelial cells [which line the heart, blood and lymph vessels] that regulates
the proliferation of lymphocytes [germ-killing white cells]…. The secretion of the
factor was effected by the pentacyclic alkaloids but not by the tetracyclic alkaloids.
Rather, it was shown that the tetracyclic alkaloids act antagonistically on the release
of the factor.”15
Falkiewicz and Lukasiak report that the POA-stimulated endothelial factor activates
normally inactive B and T lymphocytes in humans, increasing germ-killing power.14
K. Keplinger and colleagues found that in humans, the POAs increased lymphocyte
counts when they were too low, and lowered them when too high. Thus, the POAs
are both immuno-stimulating and beneficially immunoregulating.16
Samento: More than POA
The water-alcohol Samento extract also contains many other beneficial components.
Multiple quinovic acid glycosides are present as well. “These compounds are what
the latest generation of quinolone antibiotics (such as Cipro®) are based on. The
natural compounds provide safe and significant direct antimicrobial effects on Lyme
disease.”17 The quinovic glycosides also have shown antiviral activity against
rhinoviruses (cold viruses) and vesicular stomatitis virus (oral cold sores).14
Samento also contains the triterpenes oleanolic and ursolic acid. These have been
shown to have liver-protective, anti-inflammatory, antiviral, antibacterial, anti-ulcer,
immunostimulating/modulating and blood sugar-lowering properties.14 Catechin
polyphenols, including epicatechin, with anti-inflammatory and blood sugar-lowing
effects, are also present in Samento.14
Samento: Powerful Anti-Inflammatory
Cat’s claw extracts have been shown to have powerful anti-inflammatory effects. A
1998 study verified these effects through multiple in vitro and in vivo experiments.19
The cat’s claw extract reduced the production of toxic peroxynitrite, stimulated by a
bacterial toxin, and reduced subsequent cell death. Mice given Samento plus the
NSAID (non-steroidal anti-inflammatory drug) indomethacin suffered no intestinal
lining damage, yet control mice given the same dose of indomethacin without
Samento suffered complete destruction of their intestinal lining. The study’s authors
concluded: “Cat’s claw protects cells against oxidative stress and negated the
activation of NF-kB [a powerful pro-inflammatory chemical whose production is
stimulated by toxins].”
These studies provide a mechanistic evidence for the widely held belief that cat’s
claw is an effective anti-inflammatory agent.”19 Bb is known to shed membranous
materials from its surface that stimulate powerful inflammatory, autoimmune
reactions.5 In a subsequent study, the same research group found that cat’s claw
extract reduced TNF-alpha expression stimulated by a bacterial toxin 65 to 85
percent, at only nanogram levels of cat’s claw. A nanogram is one-thousandth of a
microgram! TNF-alpha is one of the most powerful pro-inflammatory cytokines
released (often to excess) by white blood cells when challenged by germ toxins.20
Samento: Clinical Use
John Kule, M.D., began using Samento in his practice in March 2002. After treating
60 patients with it, he wrote a report for the British Naturopathic Journal. He used it
to treat a broad range of conditions, including chronic fatigue, fibromyalgia,
hypertension, irritable bowel syndrome, candidiasis, gastritis, rheumatoid and
osteoarthritis, Lyme disease and benign prostatic hypertrophy. Fifty-nine out of 60
showed distinct clinical improvement.
Frequent findings were increased energy, enhanced sense of well-being, lifting of
“brain fog,” decreased inflammation, decreased blood pressure in hypertensives,
decreased fasting blood sugar in diabetics, reduced fluid retention, and reduced
blood pressure medication in hypertensives.21 He found only few, mild and transient
side effects. Several patients did experience the Herxheimer reaction (explained
later in this article).
Dr. David Jernigan, D.C., of Witchita, Kansas, uses Samento extensively for Lyme
disease and other infections. He has gotten excellent results, and has found it to be
nontoxic, active, highly energetic and synergistic with other remedies. It is a key
component for his comprehensive program of treating Lyme disease without
Dr. Lee Cowden, M.D., of Fort Worth, Texas, used Samento along with diet,
detoxification and supplements with 13 patients with documented Lyme disease,
while leaving 14 Lyme disease patients in the control group on their regular antibiotic
regimen. Three of the control group members became slightly better, three became
worse and eight were unchanged. All of the Samento group experienced dramatic
improvements, with 11 of 13 testing negative for Bb at the end of the study.17, 22
Dr. Stephen Sinatra has found Samento useful for quickly aborting bouts of the flu,
as well as preventing it.18 Samento is known to contain antiviral triterpenes and
quinovic acid glycosides, which may account for this benefit.
Samento: Slow But Steady
Due to the unique life cycle of Bb, a quick complete elimination of Bb is unrealistic to
expect, whatever germ-killers are used. Because Bb hides inside cells, often in a
dormant, cyst form, it spends much of its life cycle sequestered from antimicrobial
compounds. When cells die naturally, or from the intracellular presence of Bb, the
cysts are released into tissue fluids or blood, where they become a spirochete once
again. It is then that they are most vulnerable to antibiotics or Samento.
Since the various cells that hide Bb will typically have lifespans ranging from two to
three weeks up to six to eight months, it may take six to eight months for even one
generation of Bb to become exposed to Samento for elimination. Thus it may take
eight to 16 months to gradually kill the Bb hiding in several generations of cells.
Since Samento is extremely nontoxic,14,16 it can be safely taken daily for the “long
haul” necessary to thoroughly eradicate Bb from an infected body.
Because Samento empowers the immune system, it should not be used by those on
immunosuppressive drugs, e.g. to prevent transplant rejection, nor should it be taken
by those who are soon to undergo organ or bone marrow transplants.15 Since
Samento has been shown to lower blood pressure and blood sugar, those with
severe low blood pressure or hypoglycemia should use Samento very cautiously.21
Pregnant or nursing mothers, as well as very young children, should not use
Samento unless advised by a physician.15 Anyone taking Samento should start with
a low dose (one drop in four ounces of water twice daily) and slowly work up to five
drops two or three times daily, taken on an empty stomach. Because Samento
enhances immune activity and directly kills germs, it may trigger a Herxheimer
reaction, especially if started at too high a dose or with too rapid dose increase.
The Herxheimer reaction may include headache, muscle pain, nausea, diarrhea, or
flu-like symptoms. It is thought to be due to toxins released from the mass death of
microbes killed through treatment, as well as to the immune system’s inflammatory
overreaction to the germ toxins. Drinking lots of water and taking fiber and liver
support supplements (silymarin, dandelion root extract, lipoic acid) may reduce the
risk or severity of a Herxheimer reaction.
If such a reaction occurs when taking Samento, cease its use temporarily and restart
later at a lower dose. Those known or suspected to suffer from Lyme disease or
other serious infectious illness should ideally use Samento under the care of a
doctor or other health care professional.
1. Nutra News, Oct, 2003, p.2. www.samento.com.ec/nutranews.
2. 1 op.cit., 8.
3. Kosik-Bogacka, D. et al. Detection of Borrelia burdorferi sensu lato in mosquitoes
(Culicidae) in recreational areas of the city of Szczecin. Ann Agric Environ Med 2002, 9:55-57.
4. Harvey, W. and Salvato, P. ‘Lyme disease’: ancient engine of an unrecognized borreliosis
pandemic? Med Hypoth 2003, 60:724-59.
5. Fallon, B. and Nields, J. Lyme disease: a neuropsychiatric illness. Am J Psychiat 1994,
6. 1 op. cit., 4-5.
7. Overview of neuropsychiatric Lyme disease. www.columbialyme.
8. Fallon, B. Neuropsychiatric aspects of other infectious illnesses, in Kaplan and Sadock’s
Comprehensive Textbook of Psychiatry, by Sadock, B. and Sadock, V. (eds.), Lippincott
Williams & Wilkins, 2000. ch. 2.9.
9. The Lyme disease controversy. www.columbia-lyme.org/flatp/controv.html.
10. McCoy, J. Amy Tan, ticked off about Lyme. Wash Post 8-5-2003, HE 01.
11. 1 op. cit., 9-11.
12. Jernigan, D. and Jernigan, S. Beating Lyme Disease: Using Alternative Medicine & Goddesigned
Living. Benton, KS: Somerleyton Press, 2003. Page 16 of 31.
13. Cassarino, D. Lyme-associated Parkinsonism. Arch Pathol Lab Med 2003, 127:1204-06.
14. Falkiewicz, B. and Lukasiak, J. Vilcacora [Uncaria tomentosa (Willd.) D.C. and Uncaria
guianensis (Aublet) Gmell.] — a review of published scientific literature. Case Rep Clin Pract
Rev 2001, 2:305-16.
15. Reinhard, K-H. Uncaria tomentosa (Willd.) D.C.: Cat’s claw, Una de Gato, or Saventaro. J
Alt Comp Med 1999, 5:143-51.
16. Keplinger, K. et al. Uncaria tomentosa (Willd.) D.C. — Ethnomedical use and new
pharmacological, toxicological and botanical results. J Ethnopharmacol 1999, 64:23-34.
17. Rowen, R. The incredible healing action of one simple herb. Dr. Robert Jay Rowen’s
Second Opinion 2003, 12(12).
18. Sinatra, S. Get armed and ready for flu season. Sinatra Health Report Jan. 2004.
19. Sandoval-Chacon, M. et al. Antiinflammatory actions of cat’s claw: the role of NF-kB.
Aliment Pharmacol Ther 1998, 12:1279-89.
20. Sandoval, M. et al. Cat’s claw inhibits TNFalpha production and scavenges free radicals:
role in cytoprotection. Free Rad Biol Med 2000, 29:71-78.
21. Kule, J. Samento in the primary care setting. Br Naturopath J 2002, 19(2).
22. 1 op. cit., 1.